Clinical Trial of the Safety and Effectiveness of CHR-2797 With Erlotinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

2

Participants

Timeline

Start Date

December 31, 2007

Primary Completion Date

February 29, 2008

Study Completion Date

April 30, 2008

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

CHR-2797 (tosedostat)

Once daily, oral ingestion of CHR-2797 capsules(PhaseI: 120mg, 160mg or 200mg depending on cohort or Phase II: recommended dose) capsules until progressive disease or withdrawal from the study

DRUG

erlotinib

Once daily, oral ingestion of erlotinib tablets 150mg tablets until progressive disease or withdrawal from the study. Per protocol, the Investigator may reduce the dose of erlotinib or cease treatment with erlotinib(per label) with Sponsor approval.

Trial Locations (7)

10310

Richmond University Medical Center, Staten Island

10467

Montefiore Medical Center, The Bronx

28070

Carolina BioOncology Institute, Huntersville

28207

Clinworks Research Center, Charlotte

42003

Oncology Associates of West Kentucky, Paducah

90210

Tower Cancer Research Foundation, Beverly Hills

92868

Medical Oncology Care Associates, Orange

Sponsors
All Listed Sponsors
lead

Chroma Therapeutics

INDUSTRY

NCT00522938 - Clinical Trial of the Safety and Effectiveness of CHR-2797 With Erlotinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer | Biotech Hunter | Biotech Hunter