30
Participants
Start Date
April 30, 2001
Primary Completion Date
May 31, 2013
Study Completion Date
May 31, 2013
Paclitaxel
50 mg/m\^2 IV over one hour on Day 1, 8, 15, 22, and 29 during radiation therapy followed by 4 additional courses at 135 mg/m\^2 IV over 3 hours every 21 days, 4-6 weeks after pelvic radiation is completed.
Pelvic Radiation
Radiation therapy to the pelvis daily for 25 treatments. Beginning Day 1 or 2 and given for 5 days for 5 weeks, giving a total dose of 45 Gy with external beam radiation to the pelvis. The vaginal apex boost given either with last 3 external beam treatments or after external beam radiation completed for an additional 3 days depending on patient preference. No chemotherapy given with vaginal apex boost.
Dexamethasone
20 mg IV given 30 minutes prior to chemotherapy
Cimetidine
300 mg IV given 30 minutes prior to chemotherapy
Diphenhydramine
50 mg IV given 30 minutes prior to chemotherapy
M. D. Anderson Cancer Center - Orlando, Orlando
UT MD Anderson Cancer Center, Houston
M.D. Anderson Cancer Center
OTHER