40
Participants
Start Date
December 13, 2007
Primary Completion Date
September 2, 2010
Study Completion Date
July 4, 2012
recombinant human interleukin-21
"Patients enrolled in Part A will receive treatment daily x 5 on weeks 1, 3, and 5 of an 8 week cycle.~Patients enrolled in Part B will receive treatment daily x 5 on weeks 1, and 3 of a 6 week cycle"
immunohistochemistry staining method
Cycle 1 Day 1 and Cycle 1 Day 29
laboratory biomarker analysis
slides will be blocked for 15 minutes in 20% normal goat serum and then incubated in primary antibody
pharmacological study
Starting dose of 50μg/kg/day as an IV push
Cross Cancer Institute, Edmonton
BCCA - Fraser Valley Cancer Centre, Surrey
BCCA - Vancouver Cancer Centre, Vancouver
CancerCare Manitoba, Winnipeg
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton
Odette Cancer Centre, Toronto
CHUM - Hopital Notre-Dame, Montreal
Lead Sponsor
Collaborators (1)
ZymoGenetics
INDUSTRY
NCIC Clinical Trials Group
NETWORK