Interleukin-21 in Treating Patients With Metastatic or Recurrent Malignant Melanoma

PHASE2CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

December 13, 2007

Primary Completion Date

September 2, 2010

Study Completion Date

July 4, 2012

Conditions
Melanoma (Skin)
Interventions
BIOLOGICAL

recombinant human interleukin-21

"Patients enrolled in Part A will receive treatment daily x 5 on weeks 1, 3, and 5 of an 8 week cycle.~Patients enrolled in Part B will receive treatment daily x 5 on weeks 1, and 3 of a 6 week cycle"

OTHER

immunohistochemistry staining method

Cycle 1 Day 1 and Cycle 1 Day 29

OTHER

laboratory biomarker analysis

slides will be blocked for 15 minutes in 20% normal goat serum and then incubated in primary antibody

OTHER

pharmacological study

Starting dose of 50μg/kg/day as an IV push

Trial Locations (7)

T6G 1Z2

Cross Cancer Institute, Edmonton

V3V 1Z2

BCCA - Fraser Valley Cancer Centre, Surrey

V5Z 4E6

BCCA - Vancouver Cancer Centre, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

M4N 3M5

Odette Cancer Centre, Toronto

H2L 4M1

CHUM - Hopital Notre-Dame, Montreal

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

ZymoGenetics

INDUSTRY

lead

NCIC Clinical Trials Group

NETWORK