Effectiveness of Arginine as a Treatment for Sickle Cell Anemia

PHASE2CompletedINTERVENTIONAL
Enrollment

128

Participants

Timeline

Start Date

June 30, 2004

Primary Completion Date

September 30, 2007

Study Completion Date

January 31, 2008

Conditions
Anemia, Sickle Cell
Interventions
DRUG

Arginine

Depending on the weight of the child or adult, the patients took any where between 4-10 capsules 2 times a day. Patients weighing less than 45 kilograms were on the low dose active (or placebo) so the capsules were smaller. Patients greater than or equal to 45 kgs were on the high dose active or placebo, so these capsules were larger.

DRUG

Placebo

Depending on the weight of the child or adult, the patients took any where between 4-10 capsules 2 times a day. Patients weighing less than 45 kilograms were on the low dose active (or placebo) so the capsules were smaller. Patients greater than or equal to 45 kgs were on the high dose active or placebo, so these capsules were larger.

Trial Locations (17)

10463

Montefiore Medical Center, The Bronx

10467

Children's Hospital of Montefiore, The Bronx

19107

Thomas Jefferson University, Philadelphia

19134

St. Christopher's Children's Research Hospital, Philadelphia

19444

Children's Hospital of Philadelphia, Philadelphia

27599

University of North Carolina at Chapel Hill, Chapel Hill

27710

Duke University Medical Center, Durham

38105

St. Jude Children's Research Hospital, Memphis

39215

University of Mississippi Medical Center (Adult), Jackson

University of Mississippi Medical Center (Pediatric), Jackson

40202

Kosair Children's Hospital, Louisville

73104

Children's Hospital of Oklahoma, Oklahoma City

75390

Children's Medical Center of Dallas, Dallas

80262

University of Colorado at Denver and Health Sciences Center--Sickle Cell Treatment and Research Center, Denver

94143

University of California - San Francisco, San Francisco

94609

Children's Hospital of Oakland and Research Institute, Oakland

02118

Boston Medical Center, Boston

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

UCSF Benioff Children's Hospital Oakland

OTHER

NCT00513617 - Effectiveness of Arginine as a Treatment for Sickle Cell Anemia | Biotech Hunter | Biotech Hunter