A Study Using The Experimental Drug Called Imatinib (Gleevec) in Subjects With Systemic Sclerosis

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

August 31, 2007

Primary Completion Date

November 30, 2008

Study Completion Date

December 31, 2008

Conditions
AlveolitisSystemic Sclerosis
Interventions
DRUG

Imatinib

All subjects will receive gleevec. Subjects will have a clinic visit every 2 weeks for the first 20 weeks and then they will have one every 4 weeks for the remainder of the study. Gleevec will be taken by mouth everyday. It will be increased to a maximum of 600 mg every day. It will be increased 100 mg at each visit for the first 12 weeks. Your participation may last up to 1 year and participants will have approximately 18 clinic visits.

DRUG

Imatinib

Up to 600 mg QD PO for up to 1 year.

Trial Locations (1)

90095

UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis Pharmaceuticals

INDUSTRY

lead

University of California, Los Angeles

OTHER