Autologous and Allogenic Transplantation With Campath-1H for T-Cell Lymphoma

3 mg through the catheter Day 1 then 10 mg on Day 2, and 30 mg on Days 3 and 10 of chemotherapy treatment.

10 mg/kg subcutaneously (sc) on day +5 (in a.m.) for Stem Cell Mobilization.

250 m/m2 subcutaneously (sc) on Day +5 (in p.m.) for Stem Cell Mobilization.

300 mg/m2 IV over 1 hour on day -6

Stem cell infusion on Day 0.

Campath 15mg/day (days -6 to -4), fludarabine 30 mg/m2 IV/day (days -6 to -4) and cyclophosphamide 750 mg/m2 IV/day (1000 mg/m2 IV/day if unrelated) (days -6 to -4). Low dose total body irradiation of 2 Gy on day 0.

200 mg/m2 IV twice a day on day -5 through -2 (total 8 doses),

200 mg/m2 IV twice on day -5 to -2 (total 8 doses)

140 mg/m2 IV on day -1.

15 mg/day (days -6 to -4) for preparative regimen Allogenic Stem Cell Transplantation

30 mg/m2 IV/day (days -6 to -4)

750 mg/m2 IV/day (1000 mg/m2 IV/day if unrelated) (days -6 to -4).

Low dose total body irradiation of 2 Gy day 0.