NCT00495651 - Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) | Biotech Hunter

Enrollment

2,073

Participants

Timeline

Start Date

March 31, 2008

Primary Completion Date

January 31, 2015

Study Completion Date

January 31, 2015

Conditions

HIV InfectionsTuberculosis

Interventions

DRUG

Antiretroviral medications

Antiretroviral medications initiation at any time during the trial if at least one WHO-recommended criterion for starting ART is observed.

DRUG

Antiretroviral medications+Isoniazid prophylaxis

"* Antiretroviral initiation at any time during the trial if at least one 2009 WHO-recommended criterion for starting ART is observed.~* Isoniazid prophylaxis:300 mg of INH once a day before breakfast for six months, starting one month after study inclusion"

DRUG

Antiretroviral medications

Early ART initiation on the day of inclusion, before reaching the current WHO criteria

DRUG

Antiretroviral medications+Isoniazid prophylaxis

"* Early Antiretroviral medications initiation on the day of inclusion, before reaching the current WHO criteria~* Isoniazid prophylaxis: 300 mg of INH once a day before breakfast for six months, starting one month after study inclusion"

Trial Locations (9)

Unknown

Centre de prise en charge de personnes vivant avec le VIH la pierre angulaire, Abidjan

Centre de Prise en Charge et de Formation ACONDA, Abidjan

Centre de Suivi des donneurs de sang, Centre National de Transfusion Sanguine, Abidjan

Centre Intégré de Recherches Biocliniques d'Abidjan, Abidjan

Centre médico-social El Rapha, Abidjan

Formation Sanitaire Urbaine Anonkoua Kouté, Abidjan

Hopital Général Felix Houphouet Boigny, Abidjan

Service des Maladies Infectieuses et Tropicales, CHU de Treichville, Abidjan

Unité de Soins Ambulatoires et de Conseil, CHU de Treichville, Abidjan