Randomized Phase III Study of Folfiri+Avastin Versus Xeliri+Avastin as 1st Line Treatment of CRC

Irinotecan 150mg/m2 IV on day 1 every 2 weeks for 10 cycles

5-Fluorouracil 400 mg/m2 infused over 10 min IV and 5-FU 600 mg/m2 infused over 22 hours IV, on Day 1 and 2 (De Grammont regimen), every 2 weeks for 10 cycles

Leucovorin 200 mg/m2 infused over 2 hours IV, on day 1 and 2 every 2 weeks for 10 cycles

Capecitabine 2000mg/m2 p.o. daily, for days 1-14, every 3 weeks for 6 cycles

Bevacizumab 5mg/kg IV on day 1 every 2 weeks for 10 cycles

Bevacizumab 7,5mg/kg IV on day 1 every 3 weeks for 6 cycles

Irinotecan 250mg/m2 IV on day 1 every 3 weeks for 6 cycles