Efficacy Study of DX-88 (Ecallantide) to Treat Acute Attacks of Hereditary Angioedema (HAE)

PHASE3CompletedINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

April 1, 2007

Primary Completion Date

June 1, 2008

Study Completion Date

June 1, 2008

Conditions
Hereditary Angioedema (HAE)
Interventions
DRUG

ecallantide

dose of 30 mg (10 mg/ml) given as 3 subcutaneous injections.

DRUG

Phosphate Buffer Saline (PBS), pH 7.0

given as three 1mL subcutaneous injections.

Trial Locations (45)

1194

Jordan University Hospital, Amman

11501

Winthrop University Hospital, Mineola

15213

Childrens Hospital of Pittsburgh, Pittsburgh

17033

Penn State Milton S. Hershey Medical Center, Hershey

18045

Valley Clinical Research Center, Easton

19107

Asthma Allergy and Pulmonary Associates, Philadelphia

19718

Christiana Hospital, Newark

20007

Georgetown University Hospital, Washington D.C.

20902

Institute for Asthma and Allergy, Wheaton

23507

Clinical Research Associates of Tidewater, Norfolk

28801

Allergy Partners of Western North Carolina, Asheville

30342

Family Allergy & Asthma Center, PC, Atlanta

31904

Allergy Center of Brookstone, Columbus

33136

University of Miami, General Clinical Research Center, Miami

33401

Roberson Allergy and Asthma, West Palm Beach

33613

University of South Florida, Tampa

37620

Highlands Allergy and Asthma Center, PC, Bristol

43235

Optimed Research, LLC, Columbus

45267

University of Cincinnati, Cincinnati

47304

Muncie Allergy Center, Muncie

48038

Asthma and Allergy Institute of Michigan, Clinton Township

48197

Respiratory Medicine Research Institute of Michigan, PLC, Ypsilanti

60612

University Consultants in Allergy and Immunology, Chicago

66210

Kansas City Allergy & Asthma, Overland Park

72202

Arkansas Children's Hospital, Little Rock

72205

Little Rock Allergy & Asthma Clinic, Little Rock

75231

AARA Research Center, Dallas

77030

Baylor Clinic, Baylor College of Medicine, Houston

77802

The Paull Allergy and Asthma Clinic, P.A., Bryan

80907

Asthma and Allergy Associates, P.C., Colorado Springs

85251

Aaron J. Davis, Scottsdale

87109

Allergy Partners of Albuquerque, Albuquerque

89102

Nevada Access to Research and Education Society, Las Vegas

89503

University of Nevada School of Medicine, Reno

91344

Jacob Offenberger, Granada Hills

94704

Alta Bates Comprehensive Cancer Center, Berkeley

95531

Pacific Coast Allergy, Crescent City

98405

Puget Sound Allergy, Asthma, & Immunology, Tacoma

90095-1680

UCLA David Geffen School of Medicine, Department of Medicine, Los Angeles

02467

Brigham and Women's Hospital, Chestnut Hill

07103

UMDNJ-New Jersey Medical School, Newark

77555-1083

University of Texas Medical School, Galveston

84132-2409

University of Utah, Salt Lake City

K1Y 4G2

Allergy and Asthma Research Center, Ottawa

M4V 1R2

University of Toronto, Toronto

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Shire

INDUSTRY