54
Participants
Start Date
October 31, 2005
Primary Completion Date
November 30, 2015
Study Completion Date
November 30, 2015
rabbit anti-thymocyte globulin (ATG)
.5 mg/kg on day -3 and 2.5 mg/kg on day -2
therapeutic allogeneic lymphocytes
minimum total cluster of differentiation (CD34+) cells of 3 x 10\^6 cells/kg and a maximum of 8 x 10\^6 cells/kg will be infused on day 0
busulfan
PK-targeted continuous IV infusion over 90 hours on Days -7 to -4.
fludarabine phosphate
30 mg/m\^2/day x 5 days intravenous piggyback (IVPB) over 30 minutes on Days -7 through -3
tacrolimus
The suggested starting dose is 0.03 mg/kg po bid starting on day -1
allogeneic hematopoietic stem cell transplantation
A minimum total CD34+ cell dose of 3 x 10\^6 cells/kg and maximum of 8 x 10\^6 cells/kg will be infused on day 0
peripheral blood stem cell transplantation
minimum total CD34+ cell dose of 3 x 10\^6 cells/kg and a maximum of 8 x 10\^6 cells/kg will be infused on day 0
methotrexate
5 mg/m\^2 on days +1, +3 and +6
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill
Collaborators (1)
National Cancer Institute (NCI)
NIH
Otsuka America Pharmaceutical
INDUSTRY
UNC Lineberger Comprehensive Cancer Center
OTHER