Laser-Ranibizumab-Triamcinolone for Proliferative Diabetic Retinopathy

PHASE3CompletedINTERVENTIONAL
Enrollment

333

Participants

Timeline

Start Date

March 31, 2007

Primary Completion Date

October 31, 2009

Study Completion Date

July 31, 2010

Conditions
Proliferative Diabetic RetinopathyDiabetic Macular Edema
Interventions
DRUG

Ranibizumab

Intravitreal injection of 0.5 mg ranibizumab at baseline and 4 weeks

DRUG

Triamcinolone Acetonide

Intravitreal injection of 4 mg triamcinolone acetonide at baseline and sham injection at 4 weeks

BEHAVIORAL

Sham injection

Sham injection at baseline and 4 weeks

PROCEDURE

Focal/grid laser

Focal/grid laser for diabetic macular edema was performed 3 days to 10 days after the injection for all treatment groups.

Trial Locations (56)

10003

The New York Eye and Ear Infirmary/Faculty Eye Practice, New York

13224

Retina-Vitreous Surgeons of Central New York, PC, Syracuse

17033

Penn State College of Medicine, Hershey

19104

University of Pennsylvania Scheie Eye Institute, Philadelphia

20176

Virginia Retina Center, Leesburg

21237

Elman Retina Group, P.A., Baltimore

21801

Retina Consultants of Delmarva, P.A., Salisbury

27157

Wake Forest University Eye Center, Winston-Salem

28210

Charlotte Eye, Ear, Nose and Throat Assoc., PA, Charlotte

28211

Horizon Eye Care, PA, Charlotte

29169

Palmetto Retina Center, Columbia

29223

Carolina Retina Center, Columbia

30909

Southeast Retina Center, P.C., Augusta

33334

Retina Vitreous Consultants, Fort Lauderdale

33805

Central Florida Retina Institute, Lakeland

33912

Retina Consultants of Southwest Florida, Fort Myers

37660

Southeastern Retina Associates, PC, Kingsport

37909

Southeastern Retina Associates, P.C., Knoxville

42001

Paducah Retinal Center, Paducah

43017

OSU Eye Physicians and Surgeons, LLC., Dublin

44106

Case Western Reserve University, Cleveland

46280

Raj K. Maturi, M.D., P.C., Indianapolis

47150

John-Kenyon American Eye Institute, New Albany

52002

Medical Associates Clinic, P.C., Dubuque

53705

University of Wisconsin-Madison, Dept of Ophthalmology/Retina Service, Madison

55404

Retina Center, PA, Minneapolis

55455

University of Minnesota, Minneapolis

60435

Illinois Retina Associates, Joliet

60612

University of Illinois at Chicago Medical Center, Chicago

75231

Texas Retina Associates, Dallas

76012

Texas Retina Associates, Arlington

77025

Retina and Vitreous of Texas, Houston

77030

Vitreoretinal Consultants, Houston

78240

Retinal Consultants of San Antonio, San Antonio

78503

Valley Retina Institute, McAllen

78705

Retina Research Center, Austin

79424

Texas Retina Associates, Lubbock

79605

West Texas Retina Consultants P.A., Abilene

80027

Eldorado Retina Associates, P.C., Louisville

90211

Retina-Vitreous Associates Medical Group, Beverly Hills

90701

Sall Research Medical Center, Artesia

92262

Southern California Desert Retina Consultants, MC, Palm Springs

92354

Loma Linda University Health Care, Dept. of Ophthalmology, Loma Linda

92697

University of California, Irvine, Irvine

93103

California Retina Consultants, Santa Barbara

94598

Bay Area Retina Associates, Walnut Creek

97210

Retina Northwest, PC, Portland

97239

Casey Eye Institute, Portland

98195

University of Washington Medical Center, Seattle

04401

Maine Vitreoretinal Consultants, Bangor

21287-9277

Wilmer Ophthalmological Institute at Johns Hopkins, Baltimore

02114

Ophthalmic Consultants of Boston, Boston

02215

Joslin Diabetes Center, Boston

03801

Eyesight Ophthalmic Services, PA, Portsmouth

27599-7040

University of North Carolina, Dept of Ophthalmology, Chapel Hill

02903

Retina Consultants, Providence

Sponsors
All Listed Sponsors
collaborator

National Eye Institute (NEI)

NIH

collaborator

Genentech, Inc.

INDUSTRY

collaborator

Allergan

INDUSTRY

lead

Jaeb Center for Health Research

OTHER