691
Participants
Start Date
March 31, 2007
Primary Completion Date
December 31, 2009
Study Completion Date
February 28, 2014
Triamcinolone Acetonide + laser
4 mg intravitreal triamcinolone at randomization plus focal photocoagulation 1 week post-injection, repeated every 16 weeks with sham injections at 4-week intervals in-between. Retreatment starting at 16 weeks depends on visual acuity and OCT.
Ranibizumab + laser
0.5 mg intravitreal ranibizumab at randomization plus focal photocoagulation 1 week post-injection. Injections are repeated every 4 weeks with focal photocoagulation given post-injection every 16 weeks. Retreatment starting at 16 weeks depends on visual acuity and OCT.
Sham injection + laser
Sham injection at randomization plus focal photocoagulation 1 week post-injection. Injections are repeated every 4 weeks with focal photocoagulation given post-injection every 16 weeks. Retreatment starting at 16 weeks depends on visual acuity and OCT.
Ranibizumab + deferred laser
0.5 mg intravitreal ranibizumab at randomization, repeated every 4 weeks. Retreatment starting at 16 weeks depends on visual acuity and OCT. If improvement has not occured from injections alone, laser can be given starting at the 24 week visit.
The New York Eye and Ear Infirmary/Faculty Eye Practice, New York
Retina-Vitreous Surgeons of Central New York, PC, Syracuse
Penn State College of Medicine, Hershey
University of Pennsylvania Scheie Eye Institute, Philadelphia
Elman Retina Group, P.A., Baltimore
Retina Consultants of Delmarva, P.A., Salisbury
Wake Forest University Eye Center, Winston-Salem
Charlotte Eye, Ear, Nose and Throat Assoc., PA, Charlotte
Palmetto Retina Center, Columbia
Carolina Retina Center, Columbia
Southeast Retina Center, P.C., Augusta
University of Florida College of Med., Department of Ophthalmology, Jacksonville
Retina Vitreous Consultants, Fort Lauderdale
Central Florida Retina Institute, Lakeland
Retina Consultants of Southwest Florida, Fort Myers
Southeastern Retina Associates, PC, Kingsport
Southeastern Retina Associates, P.C., Knoxville
Paducah Retinal Center, Paducah
Case Western Reserve University, Cleveland
Retina Associates of Cleveland, Inc., Beachwood
Raj K. Maturi, M.D., P.C., Indianapolis
John-Kenyon American Eye Institute, New Albany
Medical Associates Clinic, P.C., Dubuque
Medical College of Wisconsin, Milwaukee
University of Wisconsin-Madison, Dept of Ophthalmology/Retina Service, Madison
Retina Center, PA, Minneapolis
Illinois Retina Associates, Joliet
Texas Retina Associates, Dallas
Retina and Vitreous of Texas, Houston
Vitreoretinal Consultants, Houston
Retina Research Center, Austin
Texas Retina Associates, Lubbock
West Texas Retina Consultants P.A., Abilene
Retina-Vitreous Associates Medical Group, Beverly Hills
Sall Research Medical Center, Artesia
Southern California Desert Retina Consultants, MC, Palm Springs
Loma Linda University Health Care, Dept. of Ophthalmology, Loma Linda
University of California, Irvine, Irvine
California Retina Consultants, Santa Barbara
Bay Area Retina Associates, Walnut Creek
Retina Northwest, PC, Portland
Casey Eye Institute, Portland
University of Washington Medical Center, Seattle
Retina and Vitreous Associates of Kentucky, Lexington
Wilmer Eye Institute at Johns Hopkins, Baltimore
Ophthalmic Consultants of Boston, Boston
Joslin Diabetes Center, Boston
Eyesight Ophthalmic Services, PA, Portsmouth
University of North Carolina, Dept of Ophthalmology, Chapel Hill
Retina Consultants, Providence
Lead Sponsor
Collaborators (2)
Jaeb Center for Health Research
OTHER
National Eye Institute (NEI)
NIH
Allergan
INDUSTRY
Genentech, Inc.
INDUSTRY