NCT00437957View on ClinicalTrials.gov

Phase I Study of Temozolomide, Valproic Acid and Radiation Therapy in Patients With Brain Metastases

PHASE1TerminatedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

December 31, 2006

Primary Completion Date

April 30, 2009

Study Completion Date

April 30, 2009

Conditions
Brain Metastases
Interventions
DRUG

Temozolomide

75 Mg/m2/day for all Cohorts

DRUG

Valproic Acid

Cohort 1: 20 mg/kg/day Cohort 2: 30 mg/kg/day Cohort 3: 40 mg/kg/day Cohort 4: 50 mg/kg/day

PROCEDURE

Whole Brain Radiation Therapy

Concurrently with Temozolomide and VPA

Trial Locations (1)

33612

H. Lee Moffitt Cancer Center & Research Institute, Tampa

Sponsors

Collaborators (1)

Schering-Plough
All Listed Sponsors
collaborator

Schering-Plough

INDUSTRY

lead

H. Lee Moffitt Cancer Center and Research Institute

OTHER