A Study of Bevacizumab With Carboplatin and Paclitaxel Chemotherapy for the First-Line Treatment of Patients With Metastatic Melanoma

PHASE2CompletedINTERVENTIONAL
Enrollment

214

Participants

Timeline

Start Date

February 28, 2007

Primary Completion Date

April 30, 2009

Study Completion Date

April 30, 2009

Conditions
Melanoma
Interventions
DRUG

bevacizumab

15 mg/kg by intravenous (IV) infusion on the first day of each 3-week cycle (dose was based on patient's weight at screening and remained the same throughout study)

DRUG

carboplatin

Dose based on patients' creatinine clearance (Calvert formula) and administered by intravenous (IV) infusion on the first day of each 3-week cycle, for a maximum of 10 cycles

DRUG

paclitaxel

175 mg/m\^2 by IV infusion on the first day of each 3-week cycle (dose was based on patient's weight and could be adjusted for weight change)

DRUG

placebo

Administered by IV infusion on the first day of each 3-week cycle

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY