Verteporfin Photodynamic Therapy Administered in Conjunction With Ranibizumab in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-related Macular Degeneration (AMD)

PHASE2/PHASE3TerminatedINTERVENTIONAL
Enrollment

255

Participants

Timeline

Start Date

May 31, 2007

Primary Completion Date

July 31, 2009

Study Completion Date

July 31, 2009

Conditions
Macular DegenerationChoroidal Neovascularization
Interventions
DRUG

Verteporfin Photodynamic Therapy

After a 10-minute intravenous infusion of verteporfin at a dose of 6 mg/m\^2 body surface area, verteporfin was activated by light application of 50 J/cm\^2 to the study eye, begun 15 minutes after the start of the infusion.

DRUG

Ranibizumab

Ranibizumab 0.5 mg (0.05 mL of 10 mg/mL solution for injection) administered as an intravitreal injection

DRUG

Placebo

As a placebo for verteporfin photodynamic therapy (for masking purposes), patients were administered a 10-minute intravenous infusion of 5% dextrose solution, followed by light application of 50 J/cm\^2 to the study eye, begun 15 minutes after the start of infusion.

Trial Locations (12)

Unknown

Novartis Investigative site, Vienna

Novartis Investigative site, Antwerp

Novartis Investigative site, Aalborg

Novartis Investigative site, Créteil

Novartis Investigative site, Regensburg

Novartis Investigative site, Budapest

Novartis Investigative site, Florence

Novartis Investigative site, Rotterdam

Novartis Investigative site, Warsaw

Novartis Investigative site, Madrid

Novartis Investigative site, Geneva

Novartis Investigative site, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novartis

INDUSTRY

NCT00433017 - Verteporfin Photodynamic Therapy Administered in Conjunction With Ranibizumab in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-related Macular Degeneration (AMD) | Biotech Hunter | Biotech Hunter