Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome

PHASE3CompletedINTERVENTIONAL
Enrollment

608

Participants

Timeline

Start Date

January 31, 2007

Primary Completion Date

February 28, 2014

Study Completion Date

February 28, 2014

Conditions
Marfan Syndrome
Interventions
DRUG

Losartan Potassium

Losartan .3 - 1.4 mg/kg

DRUG

Atenolol

Atenolol .5 - 4 mg/kg

Trial Locations (26)

10021

Weill Medical College of Cornell University, New York

10029

Mount Sinai Medical Center, New York

10032

Columbia College of Physicians and Surgeons, New York

15213

Children's Hospital of Pittsburgh, Pittsburgh

19104

Children's Hospital of Philadelphia, Philadelphia

Hospital of the University of Pennsylvania, Philadelphia

21205

Johns Hopkins University School of Medicine, Baltimore

27157

Wake Forest University Baptist Medical Center, Winston-Salem

27710

Duke University Medical Center, Durham

27834

Brody School of Medicine at East Carolina University, Greenville

29425

Medical University of South Carolina, Charleston

37212

Vanderbilt University Medical Center, Nashville

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

55102

Children's Hospital of Minnesota - St. Paul, Saint Paul

60614

Children's Memorial Hospital, Chicago

63110

Washington University School of Medicine, St Louis

77030

Texas Children's Hospital, Houston

84113

Primary Children's Medical Center, Salt Lake City

90048

Cedars-Sinai Medical Center, Los Angeles

92123

Rady Children's Hospital / UCSD, San Diego

94304

Lucile Packard Children's Hospital, Palo Alto

94305

Stanford University School of Medicine, Stanford

98105

Seattle Children's Hospital, Seattle

02115

Children's Hospital Boston, Boston

185 9000

Ghent University Hospital, Ghent

M5G 1X8

Hospital for Sick Children, Toronto

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

FDA Office of Orphan Products Development

FED

collaborator

National Marfan Foundation

UNKNOWN

lead

Carelon Research

OTHER

NCT00429364 - Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome | Biotech Hunter | Biotech Hunter