368
Participants
Start Date
January 31, 2004
Primary Completion Date
December 31, 2011
Study Completion Date
December 31, 2017
Dexamethasone
"10 mg/m2 daily wk 1-2 5 mg/m2 daily wk 3-4 2.5 mg/m2 daily wk 5-6 1.25 mg/m2 daily wk 7 Steroids tapered wk 8~If continuation:~Pulses every 2nd wk, 10 mg/m2 for 3 days"
Etoposide
"150 mg/m2 iv twice/wk (wk 1-2) 150 mg/m2 iv once/wk (wk 3-8)~If continuation:~150 mg/m2 iv, every 2nd wk"
Cyclosporin
"WK 1-8:~\- Aim at around 200 microgram/L (trough value). Start: 6 mg/kg daily (divided in 2 daily doses) wk 1, if kidney function is normal.~If continuation:~\- Aim for around 200 microgram/L. Monitor GFR."
Intrathecal therapy
"If at 2 wks there are progressive neurological symptoms or if an abnormal CSF (cell count and protein) has not improved, then give 4 wkly intrathecal inj. Be aware that some pat may have increased intracranial pressure.~Methotrexate: \<1 yr 6 mg, 1-2 yrs 8 mg, 2-3 yrs 10 mg, \>3 yrs 12 mg. Prednisolone: \<1 yr 4 mg, 1-2 yrs 6 mg, 2-3 yrs 8 mg, \>3 yrs 10 mg."
Stem cell transplant
The SCT procedure is up to the treating physician. However, a suggested regimen is provided.
Childhood Cancer Research Unit, Karolinska Hospital, Stockholm
Meyer Children's Hospital IRCCS
OTHER
Leiden University Medical Center
OTHER
Children's Hospital Medical Center, Cincinnati
OTHER
Ehime University Graduate School of Medicine
OTHER
Universitätsklinikum Hamburg-Eppendorf
OTHER
Baylor College of Medicine
OTHER
Great Ormond Street Hospital for Children NHS Foundation Trust
OTHER
St. Anna Kinderkrebsforschung
OTHER
Hospital de Cruces
OTHER
Hospital JP Garrahan
OTHER_GOV
Karolinska University Hospital
OTHER