20
Participants
Start Date
January 31, 2000
Primary Completion Date
February 28, 2007
Study Completion Date
February 28, 2011
Methylprednisolone pulses plus prednisone versus Cyclosporine A
The patients will be randomised to receive either MP pulses i.v. or cyclosporine A p.o. The MP pulses will consist of three doses of methylprednisolone 30 mg/kg i.v. given over a period of one week in hospital. On the intermediate days and for a month after the MP pulses, the patients will be given prednisone 30 mg/m2/day p.o., after which the prednisone medication will be gradually run down over 3 months. The patients randomised into the cyclosporine A group will receive an initial dose of 5 mg/kg/day, after which the dosage will be titrated to an optimal therapeutic level by monitoring the B-Cya concentration. The cyclosporine A treatment will be continued for 12 months.
Dept. of Pediatrics, Oulu University Hospital, Oulu
Oulu University Hospital
OTHER