Cisplatin/Etoposide/Radiotherapy Followed by Consolidation Sorafenib for Inoperable Stage III Non-Small Cell Lung Cancer

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

8

Participants

Timeline

Start Date

June 30, 2007

Primary Completion Date

April 30, 2008

Study Completion Date

April 30, 2008

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Cisplatin

Cisplatin 50 mg/m2 IV, days 1 and 8 of 28 day cycle

DRUG

Etoposide

Etoposide 50 mg/m2 IV, days 1-5 of 28 day cycle

PROCEDURE

Radiotherapy

Concurrent chest radiation (planned dose is 5940 cGy with an additional, optional boost of 1080 cGy to a total allowed dose of 7020 cGy)

DRUG

Sorafenib

Maintenance therapy of Sorafenib 400 mg PO BID, to begin a minimum of 6 and maximum of 9 weeks from completion of chemo-radiotherapy until PD, intolerable toxicity, or up to 6 months

Trial Locations (8)

45247

Oncology Partners Network, Cincinnati

46202

Indiana University Cancer Center, Indianapolis

46527

Center for Cancer Care at Goshen Health System, Goshen

46601

Northern Indiana Cancer Research Consortium, South Bend

46815

Fort Wayne Oncology & Hematology, Inc, Fort Wayne

47303

Medical Consultants, P.C., Muncie

47905

Horizon Oncology Center, Lafayette

61401

Medical & Surgical Specialists, LLC, Galesburg

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

collaborator

Amgen

INDUSTRY

collaborator

Walther Cancer Institute

OTHER

lead

Nasser Hanna, M.D.

OTHER

NCT00417248 - Cisplatin/Etoposide/Radiotherapy Followed by Consolidation Sorafenib for Inoperable Stage III Non-Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter