Thalidomide and Temozolomide or Camptothecin-11 (CPT-11) in Patients With Gliomas

PHASE2CompletedINTERVENTIONAL
Enrollment

78

Participants

Timeline

Start Date

October 31, 2003

Primary Completion Date

October 31, 2009

Study Completion Date

October 31, 2009

Conditions
Glioblastoma MultiformeGlioma
Interventions
DRUG

Thalidomide

100 mg PO (by mouth) daily for 8 weeks

DRUG

CPT-11

125 mg/m\^2 by vein weekly over 90 minutes for 4 weeks, followed by 2 weeks rest

PROCEDURE

MRI Scan

Dynamic MRI scan with dye injection through vein, every 6 weeks

PROCEDURE

Quantitative Sensory Tests (QST)

QST, every 12 weeks, to check for any nerve problems that may be present before starting treatment; by touching a small machine tests are done on feeling of touch, vibration, and temperature.

Trial Locations (1)

77030

U.T.M.D. Anderson Cancer Center, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Celgene Corporation

INDUSTRY

lead

M.D. Anderson Cancer Center

OTHER