Randomized Phase III Trial of Adjuvant Chemotherapy or Chemoradiotherapy in Resectable Gastric Cancer (CRITICS)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

788

Participants

Timeline

Start Date

January 11, 2007

Primary Completion Date

December 31, 2018

Study Completion Date

December 31, 2025

Conditions
Gastric Cancer
Interventions
DRUG

cisplatin+capecitabine

cisplatin 20 mg/m2 (i.v., q 1 w, 5 weeks), capecitabine 575 mg/m2 (b.i.d., oral, on radiotherapy days.

RADIATION

radiotherapy

45 Gy in 25 fracions (5 days/week)

DRUG

epirubicin+cisplatin+capecitabine

3 courses q 3 w: epirubicin 50 mg/m2 (i.v., day 1), cisplatin 60 mg/m2 (i.v., day 1), capecitabine 1000 mg/m2 (b.i.d., oral, day 1-14)

Trial Locations (1)

1066 CX

Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis, Amsterdam

All Listed Sponsors
collaborator

The Netherlands Cancer Institute

OTHER

collaborator

Roche Pharma AG

INDUSTRY

lead

Dutch Colorectal Cancer Group

OTHER