Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

December 31, 2006

Primary Completion Date

June 30, 2010

Study Completion Date

June 30, 2010

Conditions
Head and Neck CancerParotid Gland CancerThyroid Gland CancerMelanomaStage IV Head and Neck Cancer
Interventions
DRUG

Cisplatin

"* Two cycles during neoadjuvant therapy~* Response assessment at approximately day 36~* Concurrent biochemoradiotherapy"

DRUG

Docetaxel

"* Two cycles during neoadjuvant therapy~* Response assessment at approximately day 36~* Concurrent biochemoradiotherapy"

DRUG

Bevacizumab

"* Two cycles during neoadjuvant therapy~* Response assessment at approximately day 36~* Concurrent biochemoradiotherapy"

DRUG

Erlotinib

"* Two cycles during neoadjuvant therapy (dose escalation)~* Response assessment at approximately day 36~* Concurrent biochemoradiotherapy"

RADIATION

Radiotherapy

Radiotherapy begins as soon as possible following neoadjuvant chemotherapy, and continues for 7 weeks

Trial Locations (1)

19107

Thomas Jefferson University, Philadelphia

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Sidney Kimmel Cancer Center at Thomas Jefferson University

OTHER