Phase 2 Neoadjuvant Doxorubicin and Cyclophosphamide -> Docetaxel With Lapatinib in Stage II/III Her2Neu+ Breast Cancer

1250 mg, tablets, oral daily during treatment with docetaxel (3-week cycles x 4 cycles)

60 mg/m2, intravenously every 2 weeks for 4 cycles. Given as first treatment with cyclophosphamide.

600 mg/m2, intravenously every 2 weeks for 4 cycles. Given as first treatment with doxorubicin.

100 mg/m2, intravenously every 3 weeks for 4 cycles (after treatment cycles of doxorubicin and cyclophosphamide

6 mg, subcutaneously on day 2 of all cytotoxic chemotherapy treatments.

300 or 480 mcg, subcutaneously on days 3 to 10 after cytotoxic chemotherapies.

8 mg, oral taken twice a day for 3 days starting 24 hours before docetaxel

Loading dose 8 mg/kg, then 6 mg/kg, intravenously every 3 weeks for 1 year