High-Dose Oral Ziprasidone Versus Conventional Dosing in Participants With Residual Schizophrenia Symptoms

PHASE3CompletedINTERVENTIONAL
Enrollment

131

Participants

Timeline

Start Date

January 31, 2006

Primary Completion Date

May 31, 2011

Study Completion Date

May 31, 2011

Conditions
Schizophrenia
Interventions
DRUG

Ziprasidone 80-160 mg/d

Participants will be instructed to take one study capsule of ziprasidone orally twice daily (80 mg/d). After the first week, the study drug will be increased to two capsules twice daily (160 mg/d).

DRUG

Placebo

Participants will be instructed to take one study capsule of matching placebo orally twice daily. After the first week, the matching placebo will be increased to two capsules twice daily.

DRUG

Ziprasidone 160 mg/d

Participants will be taking open-label ziprasidone 80 mg orally twice daily for a total dose of 160 mg/d from at least 3 weeks before randomization to end of study 8 weeks after randomization.

Trial Locations (9)

10032

The Lieber Center for Schizophrenia Research - Columbia University, New York

10962

Nathan Kline Institute, Orangeburg

11203

SUNY Downstate Medical Center, Brooklyn

27509

Duke University - John Umstead Hospital, Butner

30912

Medical College of Georgia, Augusta

49503

Touchstone innovare, Grand Rapids

75024

The Mech Center, Plano

87131

University of New Mexico, Albuquerque

02720

Corrigan Mental Health Center, Fall River

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Donald C. Goff, MD

OTHER