Chemotherapy, Radiotherapy and Bevacizumab in Patients With Unresectable Stage III Non-Small-Cell Lung Cancer

PHASE2TerminatedINTERVENTIONAL
Enrollment

5

Participants

Timeline

Start Date

November 30, 2006

Primary Completion Date

January 31, 2009

Study Completion Date

January 31, 2009

Conditions
Lung Cancer
Interventions
DRUG

Bevacizumab

15mg/kg week 1, 4, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, and 49.

DRUG

Pemetrexed

500mg/m2 week 1, 4, 16, 19 and 22.

PROCEDURE

Radiotherapy

1.8 Gy single daily fractions(Monday-Friday), to total dose 61.2 Gy (7 weeks)

OTHER

Folic Acid

350 to 1,000 ug or equivalent supplementation administered orally beginning 1 to 2 weeks before the first dose of pemetrexed and continued daily until the patient discontinues study therapy.

OTHER

vitamin B12

1,000ug administered by intramuscular injection 1 to 2 weeks before the first dose of study therapy and repeated every 9 weeks until the patient discontinues therapy.

DRUG

carboplatin

AUC=5 administered intravenously weeks 1 and 4.

Trial Locations (7)

30060

Wellstar Cancer Research, Marietta

32605

Gainsville Hematology Oncology Associates, Gainesville

33805

Watson Clinic Center for Cancer Care and Research, Lakeland

37023

Tennessee Oncology, PLLC, Nashville

37404

Associates in Hematology Oncology, Chattanooga

40207

Consultants in Blood Disorders and Cancer, Louisville

45242

Oncology Hematology Care, Cincinnati

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

Eli Lilly and Company

INDUSTRY

lead

SCRI Development Innovations, LLC

OTHER