5
Participants
Start Date
November 30, 2006
Primary Completion Date
January 31, 2009
Study Completion Date
January 31, 2009
Bevacizumab
15mg/kg week 1, 4, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, and 49.
Pemetrexed
500mg/m2 week 1, 4, 16, 19 and 22.
Radiotherapy
1.8 Gy single daily fractions(Monday-Friday), to total dose 61.2 Gy (7 weeks)
Folic Acid
350 to 1,000 ug or equivalent supplementation administered orally beginning 1 to 2 weeks before the first dose of pemetrexed and continued daily until the patient discontinues study therapy.
vitamin B12
1,000ug administered by intramuscular injection 1 to 2 weeks before the first dose of study therapy and repeated every 9 weeks until the patient discontinues therapy.
carboplatin
AUC=5 administered intravenously weeks 1 and 4.
Wellstar Cancer Research, Marietta
Gainsville Hematology Oncology Associates, Gainesville
Watson Clinic Center for Cancer Care and Research, Lakeland
Tennessee Oncology, PLLC, Nashville
Associates in Hematology Oncology, Chattanooga
Consultants in Blood Disorders and Cancer, Louisville
Oncology Hematology Care, Cincinnati
Collaborators (1)
Genentech, Inc.
INDUSTRY
Eli Lilly and Company
INDUSTRY
SCRI Development Innovations, LLC
OTHER