Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection

PHASE3CompletedINTERVENTIONAL
Enrollment

813

Participants

Timeline

Start Date

September 30, 2006

Primary Completion Date

June 30, 2008

Study Completion Date

June 30, 2008

Conditions
AbscessWound InfectionDiabetic FootUlcer
Interventions
DRUG

Moxifloxacin (Avelox, BAY12-8039)

Moxifloxacin (Avelox, BAY 12-8039) 400 mg intravenous (IV) once daily followed by Moxifloxacin 400 mg oral tablets once daily for a minimum of 7 days and a maximum of 21 days. Oral phase was not always mandatory.

DRUG

Piperacillin/Tazobactam & Amoxicillin/Clavulanic acid

Piperacillin/Tacobactam 4.0/0.5 g (PIP/TAZ) administered intravenous three times daily followed by Amoxicillin/Clavulanic acid (AMC) oral tablets 875/125 mg twice daily for a minimum of 7 days and a maximum of 21 days. Oral phase not always mandatory.

Trial Locations (123)

7

Dublin

9

Dublin

1002

Riga

1005

Riga

1027

Budapest

1070

Bruxelles - Brussel

1090

Vienna

Bruxelles - Brussel

1309

Sofia

1431

Sofia

1606

Sofia

2157

Johannesburg

2650

Edegem

2880

Bornem

4032

Debrecen

5800

Pleven

6850

Worcester

7002

Rousse

7400

Kaposvár

7505

Cape Town

7531

Cape Town

7925

Cape Town

8000

Székesfehérvár

8036

Graz

Graz

8200

Veszprém

9024

Győr

9300

Dobrich

10207

Vilnius

11527

Athens

20122

Milan

20246

Hamburg

23538

Lübeck

27100

Pavia

28007

Madrid

28034

Madrid

28047

Madrid

29000

Quimper

30240

Le Grau-du-Roi

30625

Hanover

31096

Haifa

33006

Oviedo

37007

Salamanca

38043

Grenoble

39120

Magdeburg

44791

Bochum

48149

Münster

52621

Tel Litwinsky

53100

Siena

55101

Mainz

58000

Nevers

59220

Denain

59280

Tourcoing

62321

Boulogne-sur-Mer

64297

Darmstadt

65065

Odesa

65191

Wiesbaden

66013

Chieti

68135

Mannheim

74000

Annecy

76000

Ivano-Frankivsk

79659

Lviv

81377

München

84025

Avignon

88018

Uzhhorod

123567

Moscow

125206

Moscow

127486

Moscow

129110

Moscow

129327

Moscow

150003

Yaroslavl

197046

Moscow

198099

Saint Petersburg

214019

Smolensk

400006

Cluj-Napoca

700106

Iași

106 76

Athens

124 62

Athens

115 27

Athens

265 00

Rio Patras

546 36

Thessaloniki

Unknown

Wilton

Galway

Sligo

Saint Petersburg

DUBLIN 4

Dublin

00167

Roma

LV-5417

Daugavpils

LV 3400

Liepāja

LV-1038

Riga

LV-4201

Valmiera

LT-3007

Kaunas

LT-76231

Šiauliai

LT-20184

Ukmerge

1800 AM

Alkmaar

5600 PD

Eindhoven

30-501

Krakow

20-081

Lublin

20-718

Lublin

20-954

Lublin

60-479

Poznan

24-100

Puławy

02-097

Warsaw

022328

Bucharest

040215

Bucharest

050099

Bucharest

0084

Pretoria

08025

Barcelona

08036

Barcelona

08221

Terrassa (Barcelona)

01021

Kiev

01023

Kiev

01103

Kiev

01133

Kiev

SE5 9RS

London

SO22 5DG

Winchester

IV2 3UJ

Inverness

EH16 4SA

Edinburgh

M13 9WL

Manchester

G4 0SF

Glasgow

NE7 7DN

Newcastle upon Tyne

LS1 3EX

Leeds

YO13 8HE

York

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY

NCT00402727 - Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection | Biotech Hunter | Biotech Hunter