Study of Amrubicin With or Without Cisplatin Versus Etoposide-cisplatin for Extensive Stage Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

99

Participants

Timeline

Start Date

November 1, 2006

Primary Completion Date

April 1, 2010

Study Completion Date

December 1, 2010

Conditions
Small Cell Lung Cancer
Interventions
DRUG

Amrubicin

"Amrubicin 45mg/m\<2\> IV days 1, 2 3 of each 21-day cycle until disease progression.~Amrubicin 40mg/m\<2\> IV days 1, 2, 3 plus cisplatin 60mg/m\<2\> day 1 of each 21-day cycle until disease progression."

DRUG

Cisplatin

"Amrubicin 40mg/m\<2\> IV days 1, 2, 3 plus Cisplatin 60mg/m\<2\> day 1 of each 21-day cycle until disease progression.~Cisplatin 75mg/m\<2\> IV day 1 plus etoposide 100mg/m\<2\> IV day 1 and 200mg/m\<2\> orally days 2, 3 or etoposide 100mg/m\<2\> IV days 1, 2, 3 of each 21-day cycle until disease progression."

DRUG

Etoposide

Cisplatin 75mg/m\<2\> IV day 1 plus etoposide 100mg/m\<2\> IV day 1 and 200mg/m\<2\> orally days 2, 3 or etoposide 100mg/m\<2\> IV days 1, 2, 3 of each 21-day cycle until disease progression.

Trial Locations (25)

2020

Algemeen Ziekenhuis Middelheim, Antwerp

2650

Universitair Ziekenhuis Antwerpen, Edegem

3000

U.Z. Gasthuisberg, Leuven

4000

Centre Hospitalier Regional de la Citadelle, Liège

5000

Clinique Sainte Elisabeth, Namur

6202

Academisch Ziekenhuis Maastricht, Maastricht

8001

Isala Kliniek, Zwolle

9000

Universiteit Gent, Ghent

16132

Instituto Nazionale per la Ricerca sul Cancro, Genova

33100

Universita Degli Studi Di Udine, Udine

80211

Medical University of Gdansk - Dept Radiotherapy, Gdansk

1BE

Domaine Universitaire du Sart-Tilman, Liège

1105 AZ

Academisch Medisch Centrum, Amsterdam

Unknown

The Netherlands Cancer Institute Antoni Van Leeuwenhoekziekenhuis, Amsterdam

7500 KA

Medisch Spectrum Twente - Dept of Pulmonary Diseases, Enschede

2300RC

Leiden University Medical Centre, Leiden

CH684JY

Clatterbridge Centre for Oncology NHS Trust, Bebington

D01 9SY

University of Dundee - Ninewells Hospital, Dundee

BT9 7AB

Belfast City Hospital, Belfast

EH4 2XU

Western General Hospital, Edinburgh

HU8 9HE

Princess Royal Hospital, Hull

SM2 5PT

Royal Marsden Hospital, London, London

M20 4BX

Christie Hospital, Manchester

NE4 6BE

Sir Bobby Robson Cancer Trials Research Centre, Newcastle upon Tyne

(Surrey) SM2 5PT

Royal Marsden Hospital Lung Unit, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY