Effects of Two Anti-HIV Drug Regimens on HIV Transmission Risk Behavior Among SMART Study Participants

CompletedOBSERVATIONAL
Enrollment

883

Participants

Timeline

Start Date

January 31, 2002

Primary Completion Date

January 31, 2006

Study Completion Date

September 30, 2008

Conditions
HIV Infections
Interventions
DRUG

Delayed ART

Participants follow a drug conservation (DC) regimen in which ART is stopped or deferred until CD4 cell count dropped below 250 cells/mm3, initiated until CD4 cell count is at least 350 cells/mm3, and then are followed by episodic ART based on CD4 cell count.

DRUG

Continuous ART

Group 2 participants follow a viral suppression (VS) regimen in which ART was continued to keep viral loads as low as possible, regardless of CD4 cell count.

Trial Locations (58)

10011

St. Vincent Hosp. & Med. Ctr. CRS, New York

10452

Bronx Prevention Center CRS, The Bronx

10457

Bronx-Lebanon Hosp. Ctr. CRS, The Bronx

10467

Montefiore Med. Ctr., AIDS Ctr. CRS, The Bronx

19107

Philadelphia FIGHT - Dr. Jay Kostman CRS, Philadelphia

19140

Temple Univ. School of Medicine CRS, Philadelphia

19141

Albert Einstein Med. Ctr., Immunodeficiency Ctr. CRS, Philadelphia

20422

Washington DC VAMC, Washington Regional AIDS Program, Infectious Diseases CRS, Washington D.C.

22401

MediCorp, Infectious Disease Associates CRS, Fredericksburg

23116

Hanover Med. Park (Mechanicsville, VA) CRS, Mechanicsville

23223

Vernon Harris East End Community Health Ctr. CRS, Richmond

23224

CrossOver Health Ctr. CRS, Richmond

South Richmond Health Care Ctr. CRS, Richmond

23249

Hunter Holmes McGuire VAMC CRS, Richmond

23298

VCU Health Systems, Infectious Disease Clinic CRS, Richmond

23507

Eastern Virginia Med. School, Ctr. for the Comprehensive Care of Immune Deficiency CRS, Norfolk

23803

Petersburg Health Care Alliance CRS, Petersburg

30033

Atlanta VAMC CRS, Decatur

33125

Miami VAMC CRS, Miami

48201

Harper Hosp., Detroit CRS, Detroit

Wayne State Univ. CRS, Detroit

Wayne State Univ. INSIGHT CRS, Detroit

48215

Detroit Community Health Connection, Inc. CRS, Detroit

49503

McAuley Health Ctr. CRS, Grand Rapids

80033

Western Infectious Disease Consultants CRS, Wheat Ridge

80204

Denver Public Health CRS - INSIGHT, Denver

Denver Public Health CRS, Denver

80205

Eastside Family Health Ctr. CRS, Denver

80220

Denver VAMC CRS, Denver

90211

AIDS Healthcare Foundation CRS, Beverly Hills

93702

UCSF, Fresno, School of Medicine, Dept. of Internal Medicine CRS, Fresno

94102

Dr. Shawn Hassler Med. Practice CRS, San Francisco

94110

Positive Health Program Clinic (San Francisco Gen. Hosp.) CRS, San Francisco

94114

Castro-Mission Health Ctr. CRS, San Francisco

94121

San Francisco VAMC, Infectious Diseases Clinic CRS, San Francisco

94143

UCSF PHP, Gen. Internal Medicine Practice CRS, San Francisco

94609

Dr. Robert Scott Med. Practice CRS, Oakland

East Bay AIDS Ctr. CRS, Oakland

97204

Multnomah County Health Dept., HIV Health Services Ctr. CRS, Portland

97210

Legacy Clinic Good Samaritan CRS, Portland

The Research & Education Group-Portland CRS, Portland

97213

Providence Portland Med. Ctr., Ambulatory Care and Education Ctr. CRS, Portland

97227

Kaiser Immune Deficiency Clinic of Portland CRS, Portland

Legacy Clinic Emanuel CRS, Portland

97239

Oregon Health & Sciences Univ. Internal Medicine (L-475) CRS, Portland

97401

PeaceHealth Med. Group - Hilyard Street Clinic CRS, Eugene

94941-3013

Dr. M. Estes Med. Practice CRS, Mill Valley

94114-1010

Dr. Virginia Cafaro Med. Practice CRS, San Francisco

Dr. William Owen Med. Practice CRS, San Francisco

80501-4507

Beacon Clinic at Boulder CRS, Boulder

80204-4507

Denver Infectious Diseases Consultants CRS, Denver

Kaiser Permanente of Denver CRS, Denver

Univ. of Colorado Health Science Ctr. CRS, Denver

08103

Cooper Univ. Hosp. CRS, Camden

Unknown

Cooper Hospital/Univ. Med. Ctr., The Cooper Early Intervention Program (EIP) CRS, Camden

07103

New Jersey Medical School- Adult Clinical Research Ctr. CRS, Newark

08244

South Jersey Infectious Disease, Cape Clinical Trials CRS, Somers Point

08043

The Early Intervention Program at Kennedy Hosp. CRS, Voorhees Township

All Listed Sponsors
collaborator

Community Programs for Clinical Research on AIDS

NETWORK

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT00386035 - Effects of Two Anti-HIV Drug Regimens on HIV Transmission Risk Behavior Among SMART Study Participants | Biotech Hunter | Biotech Hunter