Erlotinib Before and After Surgery in Treating Patients With Muscle-Invasive Bladder Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

May 31, 2006

Primary Completion Date

August 31, 2010

Study Completion Date

June 30, 2014

Conditions
Bladder Cancer
Interventions
DRUG

Erlotinib

Erlotinib will be given at a dose of 150 mg per day for 4 weeks before undergoing planned radical cystectomy. In addition, patients will continue on erlotinib daily at a dose of 150 mg per day (qd dosing) for up to 2 years after surgery (beginning within 12 weeks of surgery) or until evidence of disease recurrence or progression

PROCEDURE

Radical Cystectomy

Will occur 4 weeks prior to dosing with erlotinib

Trial Locations (1)

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

OSI Pharmaceuticals

INDUSTRY

collaborator

National Cancer Institute (NCI)

NIH

lead

UNC Lineberger Comprehensive Cancer Center

OTHER