Therapy With Bevacizumab (BEV), Doxorubicin, and Cyclophosphamide Followed by BEV, Docetaxel, and Capecitabine Before Surgery Followed by BEV Alone After Surgery for Women With Locally Advanced Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

August 31, 2006

Primary Completion Date

February 29, 2008

Study Completion Date

November 30, 2009

Conditions
Breast Cancer
Interventions
DRUG

Bevacizumab

15 mg/kg IV every 21 days x 4 cycles, then after clinical response assessment, 15 mg/kg IV every 21 days x 2 cycles, then following surgery, 15 mg/kg every 21 days x 10 cycles

DRUG

Doxorubicin

60 mg/m\^2 IV every 21 days x 4 cycles

DRUG

Cyclophosphamide

600 mg/m\^2 IV every 21 days x 4 cycles

DRUG

Capecitabine

Following clinical response assessment, 650 mg/m\^2 twice a day (orally), days 1-14 every 21 days x 4 cycles

DRUG

Docetaxel

Following clinical response assessment, 75 mg/m\^2 IV every 21 days x 4 cycles

Trial Locations (1)

15212

NSABP Foundation, Inc., Pittsburgh

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

Hoffmann-La Roche

INDUSTRY

collaborator

International Drug Development Institute

OTHER

lead

NSABP Foundation Inc

NETWORK