Study of FOLFIRI Plus Bevacizumab in Colorectal Cancer Patients

PHASE2CompletedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

January 31, 2005

Primary Completion Date

March 31, 2011

Study Completion Date

March 31, 2011

Conditions
Colorectal Cancer
Interventions
DRUG

5-Fluorouracil

"400 mg/m\^2 injection by vein Day 1 of 14 day cycle immediately after completion of leucovorin infusion.~2.4 g/m\^2 by vein over 46 hours over Days 1-3 of 14 day cycle immediately after completion of 400 mg/m\^2 injection."

DRUG

Bevacizumab

"5 mg/kg over 90 minutes on Day 1 of first 14 day cycle as initial dose, administered alone without other drugs.~5 mg/kg by vein on Day 1 of 14 day cycle."

DRUG

Leucovorin

400 mg/m\^2 over 2-4 minutes by vein on Day 1 of 14 day cycle.

DRUG

Irinotecan

180 mg/m\^2 by vein over 90 minutes on Day 1 of 14 day cycle.

Trial Locations (2)

77030

Lyndon Baines Johnson General Hospital, Houston

UT MD Anderson Cancer Center, Houston

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

Pfizer

INDUSTRY

lead

M.D. Anderson Cancer Center

OTHER