NCT00346801View on ClinicalTrials.gov

CPT-11/Cisplatin and Celecoxib With Radiation Therapy for Patients With Unresectable Non-Small Cell Lung Cancer (NSCLC)

PHASE1CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

September 30, 2003

Primary Completion Date

October 31, 2012

Conditions
Lung Cancer
Interventions
DRUG

Celecoxib

100 mg by mouth (PO) twice daily for 5 days before beginning radiation therapy; continued 7 days per week throughout radiation treatment (about 7 weeks).

DRUG

Cisplatin

25 mg/m\^2 IV over 60 minutes on Day 1, Weeks 2-8

DRUG

CPT-11

30 mg/m\^2 IV over 90 minutes on Day 1, Weeks 2-8, followed by cisplatin which will be infused for 60 minutes.

RADIATION

Concurrent Thoracic Radiation Therapy

63 Gy at 1.8 Gy/Fx in 35 Fractions over 7 weeks starting 2nd week of celebrex.

Trial Locations (1)

77030

UT MD Anderson Cancer Center, Houston

All Listed Sponsors
collaborator

National Comprehensive Cancer Network

NETWORK

lead

M.D. Anderson Cancer Center

OTHER

NCT00346801 - CPT-11/Cisplatin and Celecoxib With Radiation Therapy for Patients With Unresectable Non-Small Cell Lung Cancer (NSCLC) | Biotech Hunter | Biotech Hunter