Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

248

Participants

Timeline

Start Date

August 31, 2008

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Colorectal Cancer
Interventions
DRUG

fluorouracil

Given IV

DRUG

leucovorin calcium

Given IV

DRUG

oxaliplatin

Given IV

PROCEDURE

conventional surgery

Patients undergo surgery

RADIATION

radiation therapy

Patients undergo radiotherapy

OTHER

laboratory biomarker analysis

Correlative studies

GENETIC

DNA analysis

Correlative studies

GENETIC

polymerase chain reaction

Correlative studies

OTHER

immunohistochemistry staining method

Correlative studies

Trial Locations (15)

20010

Washington Cancer Institute at Washington Hospital Center, Washington D.C.

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

55455

Masonic Cancer Center at University of Minnesota, Minneapolis

63110

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis

68114

Colon and Rectal Surgery, Incorporated, Omaha

92868

Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center, Orange

94115

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

94524-4110

Cancer Care Center at John Muir Health - Concord Campus, Concord

91010-3000

City of Hope Medical Center, Duarte

92868-3849

St. Joseph Hospital Regional Cancer Center - Orange, Orange

33612-9497

H. Lee Moffitt Cancer Center and Research Institute at University of South Florida, Tampa

60637-1470

University of Chicago Cancer Research Center, Chicago

97239-3098

Knight Cancer Institute at Oregon Health and Science University, Portland

05405-0110

Vermont Cancer Center at University of Vermont, Burlington

T2N 4N2

Tom Baker Cancer Centre - Calgary, Calgary

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Memorial Sloan Kettering Cancer Center

OTHER