Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery

PHASE3CompletedINTERVENTIONAL
Enrollment

77

Participants

Timeline

Start Date

May 31, 2006

Primary Completion Date

December 31, 2009

Study Completion Date

December 31, 2009

Conditions
Heart Defects, CongenitalHypertension, Pulmonary
Interventions
DRUG

L-citrulline

150mg bolus X 1 after initiation of cardiopulmonary bypass followed by continuous infusion of 9mg/kg/hr IV, starting 4 hours post bolus administration and ending at 48 hours continuous infusion or discharge from the PCCU

DRUG

Placebo of intravenous L-citrulline

Placebo of intravenous L-citrulline

Trial Locations (1)

37232

Vanderbilt University Medical Center, Nashville

Sponsors
All Listed Sponsors
collaborator

Vanderbilt University

OTHER

lead

Asklepion Pharmaceuticals, LLC

INDUSTRY