Abraxane and Lapatinib in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

May 4, 2006

Primary Completion Date

November 10, 2006

Study Completion Date

August 5, 2010

Conditions
Breast Cancer
Interventions
DRUG

lapatinib ditosylate

Oral lapatinib is taken once daily on days 1-21 of each treatment cycle. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.

DRUG

paclitaxel albumin-stabilized nanoparticle formulation

30 patients receive Abraxane IV over 30 minutes on day 1 each of each treatment cycle. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.

Trial Locations (5)

60432

Midwest Center for Hematology/Oncology, Joliet

60461

Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields, Olympia Fields

60611

Hematology-Oncology Associates of Illinois, Chicago

60611-3013

Northwestern University, Northwestern Medical Faculty Foundation, Chicago

79410-1894

Joe Arrington Cancer Research and Treatment Center, Lubbock

Sponsors
All Listed Sponsors
collaborator

GlaxoSmithKline

INDUSTRY

collaborator

Celgene Corporation

INDUSTRY

lead

Northwestern University

OTHER