A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure

PHASE3CompletedINTERVENTIONAL
Enrollment

318

Participants

Timeline

Start Date

March 31, 2006

Primary Completion Date

April 30, 2008

Study Completion Date

June 30, 2008

Conditions
Congestive Heart Failure
Interventions
DRUG

carvedilol controlled release

Carvedilol controlled release (10, 20, 40 or 80 mg) and placebo taken in the morning. Two placebos taken in the evening. A total of 4 pills will be taken PO daily.

DRUG

carvedilol immediate release

Carvedilol immediate release (3.125, 6.25, 12.5 or 25 mg) and placebo, taken PO, twice-daily.

Trial Locations (75)

10035

New York Cardiovascular Associates, New York

10467

Montefiore Medical Center, The Bronx

11501

Long Island Heart Associates, Mineola

11795

South Bay Cardiovascular Associates, West Islip

12205

Albany Associates in Cardiology, Albany

14215

Buffalo Heart Group, LLP, Buffalo

15009

Tri-State Medical Group, Beaver

16602

Blair Medical Associates, Altoona

16866

Mid State Medical Service, Philipsburg

18901

Central Bucks Specialists, Doylestown

18960

Buxmont Cardiology Associates, PC, Sellersville

19148

Cardiology Consultants of Philadelphia, Philadelphia

21215

One Heart, LLC, Baltimore

22601

Winchester Medical Center, Winchester

27157

Wake Forest University Baptist Medical Center, Winston-Salem

27401

LeBauer Cardiovascular Research Foundation, Greensboro

27599

University of North Carolina, Chapel Hill

29204

South Carolina Heart Center, Columbia

29403

Charleston Cardiology, Charleston

30165

Harbin Clinic, Rome

30309

Cardiac Disease Specialists, PC, Atlanta

32547

White-Wilson Medical Center, PA, Fort Walton Beach

33410

Palm Beach Cardiology, Palm Beach Gardens

33511

Bay Area Cardiology, Brandon

33756

Clearwater Cardiovascular and Interventional Consultants, Clearwater

36608

Cardiology Associates, Mobile

Mobile Heart Specialists, Mobile

38801

Cardiology Associates Research, LLC, Tupelo

40205

Cardiovascular Associates, Louisville

40207

Louisville Cardiology Medical Group, Louisville

41042

Comprehensive Cardiology Associates, Florence

43615

Northwest Ohio Cardiology Consultants, Toledo

45219

Sterling Research Group Ltd., Cincinnati

The Lindner Clinical Trial Center, Cincinnati

46260

The Care Group LLC, Indianapolis

47130

River Cities Cardiology, Jeffersonville

50266

Iowa Heart Center, West Des Moines

54303

Green Bay HeartCare, Green Bay

54702

Luther Midelfort Mayo Health Systems, Eau Claire

55101

Regions Hospital Cardiology Research, Saint Paul

55102

St. Paul Cardiology, Saint Paul

55415

Hennepin County Medical Center, Minneapolis

55435

Minnesota Heart Clinic, Edina

59901

Rocky Mountain Heart & Lung, Kalispell

60015

North Shore Cardiovascular Research Consortium, Bannockburn

60202

Saint Francis Hospital, Evanston

60521

Illinois Heart and Vascular, Hinsdale

61107

Rockford Cardiology Research Foundation, Rockford

61614

HeartCare Midwest, Peoria

62701

Prairie Cardiovascular Consultants, Springfield

66160

Mid-America Cardiology, Kansas City

67214

Via Christi Research, Inc., Wichita

73120

Oklahoma Cardiovascular Research Group, Oklahoma City

77546

Heart Specialists, Friendswood

79410

Texas Cardiac Center, Lubbock

80218

Aurora Denver Cardiology Associates, Denver

80538

Medical Center of the Rockies Foundation, Loveland

84107

Intermountain Medical Center, Murray

84124

Heart Center, Salt Lake City

85054

Mayo Clinic Arizona, Phoenix

85251

Scottsdale Cardiovascular Research Institute, Scottsdale

85715

South West Heart, Tucson

90242

Rancho Los Amigos USC, Downey

91405

Medvin Clinical Research, Van Nuys

92120

Southern California Cardiology Medical Group, Inc., San Diego

92879

Inland Heart Doctors Medical Group, Corona

95340

Merced Heart Associates, Merced

95448

William Bowden, DO Private Practice, Healdsburg

95819

Sutter Memorial Hospital, Sacramento

97330

Samaritan Cardiology, Corvallis

33137-3732

South Florida International Cardiology Consultants, Inc., Miami

07052

Diagnostic and Clinical Cardiology, West Orange

87131-0001

University of New Mexico, Albuquerque

45267-0542

University Hospital, Cincinnati

02903

Rhode Island Heart Failure Center, Providence

All Listed Sponsors
collaborator

CTI Clinical Trial and Consulting Services

OTHER

collaborator

GlaxoSmithKline

INDUSTRY

lead

CTI-1, LLC

INDUSTRY