Safety and Efficacy of Repeated Intravitreal Administration of Vascular Endothelial Growth Factor (VEGF) Trap in Patients With Wet Age-Related Macular Degeneration (AMD)

PHASE2CompletedINTERVENTIONAL
Enrollment

159

Participants

Timeline

Start Date

April 30, 2006

Primary Completion Date

June 30, 2008

Study Completion Date

August 31, 2008

Conditions
Macular Degeneration
Interventions
BIOLOGICAL

aflibercept injection (VEGF Trap-Eye, BAY86-5321)

Participants received 0.5 mg of aflibercept injection (VEGF Trap-Eye, BAY86-5321) at 4 week intervals through Week 12

BIOLOGICAL

aflibercept injection (VEGF Trap-Eye, BAY86-5321)

Participants received 0.5 mg of aflibercept injection (VEGF Trap-Eye, BAY86-5321) at 12 week intervals through Week 12.

BIOLOGICAL

aflibercept injection (VEGF Trap-Eye, BAY86-5321)

Participants received 2.0 mg of aflibercept injection (VEGF Trap-Eye, BAY86-5321) at 4 week intervals through Week 12

BIOLOGICAL

aflibercept injection (VEGF Trap-Eye, BAY86-5321)

Participants received 2.0 mg of aflibercept injection (VEGF Trap-Eye, BAY86-5321) at 12 week intervals through Week 12.

BIOLOGICAL

aflibercept injection (VEGF Trap-Eye, BAY86-5321)

Participants received 4.0 mg of aflibercept injection (VEGF Trap-Eye, BAY86-5321) at 12 week intervals through Week 12.

Trial Locations (18)

10189

New England Retina Consultants PC, West Springfield

19107

Retina Diagnostic and Treatment Assoc., LLC, Philadelphia

21287

Johns Hopkins Hospital School of Medicine, Baltimore

28210

Charlotte Eye, Ear, Nose & Throat Asssociates, Charlotte

30909

Southeast Retina Center, Augusta

37203

Retina-Vitreous Associates, P.C., Nashville

46280

Midwest Eye Institute, Indianapolis

57701

Black Hills Regional Eye Institute, Rapid City

60637

University of Chicago, Chicago

73104

Dean A. McGee Eye Institute, Oklahoma City

77030

Vitreoretinal Consultants Scurlock Tower Texas Medical Center, Houston

78240

Medical Center Ophthamology, San Antonio

85020

Associated Retina Consultants, Phoenix

85704

Retina Centers, PC, Tucson

90211

Retina Vitreous Associates Medical Group, Beverly Hills

92354

Loma Linda University Health Care, Loma Linda

97210

Retina Northwest PC, Portland

02114

Ophthalmic Consultants of Boston, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

lead

Regeneron Pharmaceuticals

INDUSTRY