Cetuximab and Radiation Therapy for Surgically Resectable Esophageal and Gastroesophageal (GE) Junction Carcinomas

PHASE2CompletedINTERVENTIONAL
Enrollment

41

Participants

Timeline

Start Date

April 30, 2006

Primary Completion Date

January 31, 2009

Study Completion Date

January 31, 2009

Conditions
Esophageal Cancer
Interventions
PROCEDURE

Radiation Therapy

External beam radiation therapy, beginning on day 1, 4500 cGy to esophagus with boost of 540 cGy at 180 cGy per fraction for 6 weeks

PROCEDURE

Surgery

Surgical resection of primary tumor and adjacent mediastinal and/or celiac lymph nodes by a transthoracic approach after satisfactory hematologic and functional recovery within 8 weeks of completion of radiation therapy

PROCEDURE

Tissue Sample

For patients who give their consent, fresh frozen tissue will be obtained per EUS at baseline, per EUS 2 weeks after the initiation of chemotherapy, and at the time of surgery for pathology submission

Trial Locations (7)

46202

Indiana University Cancer Center, Indianapolis

46256

Community Regional Cancer Center, Indianapolis

47804

AP&S Clinic, Terre Haute

61401

Medical & Surgical Specialists, LLC, Galesburg

63110

Siteman Cancer Center, St Louis

75246

Texas Oncology, PA, Dallas

75390

University of Texas Southwestern Medical Center at Dallas, Dallas

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Walther Cancer Institute

OTHER

lead

Nasser Hanna, M.D.

OTHER