NCT00295542View on ClinicalTrials.gov

Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy

PHASE4CompletedINTERVENTIONAL
Enrollment

3,344

Participants

Timeline

Start Date

March 31, 2000

Primary Completion Date

April 30, 2009

Study Completion Date

April 30, 2009

Conditions
Hypertension
Interventions
DEVICE

Ambulatory blood pressure monitoring

Sampling at 20-min intervals from 07:00 to 23:00 hours and at 30-min intervals at night for 48 consecutive hours

PROCEDURE

Chronotherapy, timing of antihypertensive medication

Comparison of effects of awakening versus bedtime dosing

DRUG

ACEI (including spirapril, enalapril, quinapril, lisinopril)

Treatment at awakening versus bedtime

DRUG

ARB (including valsartan, telmisartan, olmesartan)

Treatment at awakening versus bedtime

DRUG

beta blockers (including nebivolol, atenolol, carvedilol)

Treatment at awakening versus bedtime

DRUG

diuretics (torasemide, indapamide, HTCZ) and doxazosin

Treatment at awakening versus bedtime

PROCEDURE

Combination therapy in essential hypertension

Treatment at awakening versus bedtime

Trial Locations (1)

15706

Hospital Clinico Universitario, Santiago de Compostela

All Listed Sponsors
collaborator

Hospital Clinico Universitario de Santiago

OTHER

collaborator

Ministry of Work and Welfare - Xunta de Galicia

OTHER_GOV

collaborator

Ministerio de Educacion y Ciencia, Spain

UNKNOWN

lead

University of Vigo

OTHER

NCT00295542 - Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy | Biotech Hunter | Biotech Hunter