Efficacy and Safety of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD)

PHASE3CompletedINTERVENTIONAL
Enrollment

353

Participants

Timeline

Start Date

December 31, 2005

Primary Completion Date

January 31, 2008

Study Completion Date

January 31, 2008

Conditions
Age Related Macular Degeneration
Interventions
DRUG

Ranibizumab 0.3 mg - 3 times monthly, then quarterly

Subjects received intravitreal injections (in the study eye) of ranibizumab 0.3 mg over a duration of 12 months. They were treated monthly for 3 consecutive months and then quarterly for the remainder of the study. On those months when ranibizumab was not administered, patients received a sham injection to preserve the masking of the treatment arms.

DRUG

Ranibizumab 0.5 mg - 3 times monthly, then quarterly

Subjects received intravitreal injections (in the study eye) of ranibizumab 0.5 mg over a duration of 12 months. They were treated monthly for 3 consecutive months and then quarterly for the remainder of the study. On those months when ranibizumab was not administered, patients received a sham injection to preserve the masking of the treatment arms.

DRUG

Ranibizumab 0.3 mg monthly

Subjects received monthly intravitreal injections (in the study eye) of ranibizumab 0.5 mg over a duration of 12 months. On those months when ranibizumab was not administered, patients received a sham injection to preserve the masking of the treatment arms.

Trial Locations (1)

4002

Novartis, Basel

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novartis

INDUSTRY