NCT00275535 - The Comparison of Tacrolimus and Sirolimus Immunosuppression Based Drug Regimens in Kidney Transplant Recipients | Biotech Hunter

Enrollment

165

Participants

Timeline

Start Date

April 30, 2001

Primary Completion Date

November 30, 2007

Study Completion Date

December 31, 2008

Conditions

Kidney Diseases

Interventions

DRUG

Anti-thymocyte globulin

Thymoglobulin 1.5 mg/kg/d (days 0,1,2,4,6)

DRUG

Mycophenolate mofetil

Mycophenolate mofetil 750 mg p.o. b.i.d.- maintenance

DRUG

Prednisone

Prednisone 500 mg/day initially, tapered to 5 mg/day by day 92

DRUG

Tacrolimus

Tacrolimus - maintain trough levels of 6-8 ng/ml (whole blood Imx assay)

DRUG

Sirolimus

Rapamycin 3 to 5 mg/day; adjust to the high-performance liquid chromatography (HPLC) blood level 15 to 20 ng ml

Trial Locations (1)

Mayo Clinic, Rochester