Efficacy of Lapaquistat Acetate Alone or Combined With Rosuvastatin in Subjects With Hypercholesterolemia

PHASE3CompletedINTERVENTIONAL
Enrollment

415

Participants

Timeline

Start Date

October 31, 2005

Primary Completion Date

April 30, 2007

Study Completion Date

April 30, 2007

Conditions
Hypercholesterolemia
Interventions
DRUG

Lapaquistat acetate and rosuvastatin

Lapaquistat acetate 50 mg, tablets, orally, once daily and stable Rosuvastatin therapy (10 or 20 mg) for up to 24 weeks.

DRUG

Lapaquistat acetate and rosuvastatin

Lapaquistat acetate 100 mg, tablets, orally, once daily and stable Rosuvastatin therapy (10 or 20 mg) for up to 24 weeks.

DRUG

Rosuvastatin

Lapaquistat acetate placebo-matching tablets, orally, once daily and stable Rosuvastatin therapy (10 or 20 mg) for up to 24 weeks.

Trial Locations (92)

Unknown

Birmingham

Haleyville

Mobile

Scottsdale

Long Beach

Mission Viejo

Orange

Redondo Beach

Rolling Hills Estates

San Diego

Torrance

Tustin

Avon

Bristol

DeLand

Fort Lauderdale

Hialeah

Jacksonville

Jupiter

Melbourne

Miami

Naples

Ocala

Pembroke Pines

Plantation

Hayden Lake

Meridian

Arlington Heights

Aurora

Chicago

Peoria

Indianapolis

Iowa City

Kansas City

Witchita

Louisville

Thibodaux

Auburn

Haverhill

Benzonia

Detroit

Kansas City

St Louis

Missoula

Concord

West Seneca

Raleigh

Statesville

Winstom-Salem

Grand Forks

Akron

Cincinnati

Columbus

Kettering

Tulsa

Eugene

Portland

Lansdale

Philadelphia

Pittsburgh

Scotland

Cranston

Anderson

Bristol

Cordova

Kingsport

Austin

Dallas

Houston

McKinney

Midland

San Antonio

Salt Lake City

Burke

Norfolk

Richmond

Weber City

Bellevue

Burien

Edmonds

Seattle

Spokane

Calgary

Portage la Prairie

London

Oakville

Oshawa

Thornhill

Toronto

Chicoutimi

Saint-Jérôme

Ste-Foy

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Takeda

INDUSTRY