NCT00223717 - Treatment of Supine Hypertension in Autonomic Failure | Biotech Hunter

Enrollment

152

Participants

Timeline

Start Date

January 31, 2001

Primary Completion Date

January 31, 2017

Study Completion Date

January 31, 2017

Conditions

Hypertension

Interventions

DRUG

Clonidine

0.1-0.2mg po. Single dose.

DRUG

Nitroglycerin transdermal

0.05-0.2 mg patch. 1 application. Alone or in combination with DDAVP.

DRUG

Dipyridamole/ Aspirin (Aggrenox)

dipyridamole 200 mg and aspirin 25 mg po. Single dose.

DRUG

Desmopressin (DDAVP)

0.2 - 0.6mg po. Single dose. Alone or in combination with nitroglycerin transdermal or nifedipine

DRUG

Sildenafil

25- 100 mg po. Single dose.

DRUG

Nifedipine

10-30 mg po. Single dose.

DRUG

Hydralazine

10-50 mg po. Single dose

DRUG

Hydrochlorothiazide

12.5-100 mg po. Single dose.

DRUG

Placebo

Po or patch. Single dose.

DRUG

Bosentan

62.5 -125 mg po. Single dose.

DRUG

Diltiazem

30-60 mg po. Single dose.

DRUG

Eplerenone

50-100 mg po. Single dose.

DRUG

guanfacine

1-3 mg po. Single dose.

DIETARY_SUPPLEMENT

L-arginine

6-17 g po. Single dose

DRUG

captopril

25-50 mg PO. Single dose.

DRUG

carbidopa

25-200 mg PO. Single dose.

DRUG

losartan

25-200 mg PO. Single dose.

DRUG

metoprolol tartrate

25-100 mg PO. Single dose.

DRUG

nebivolol hydrochloride

2.5-40 mg PO. Single dose.

DRUG

prazosin hydrochloride

0.5-1 mg PO. Single dose.

DRUG

tamsulosin hydrochloride

0.4-0.8 mg PO. Single dose.

OTHER

Head-up tilt.

Head of the bed elevated 10 degrees (7 inch) or whole bed tilted head-up 5 degrees in reverse trendelenburg (head of the bed elevated 7 inches)

DRUG

aliskiren

aliskiren (Tekturna) 150-300mg po single dose

OTHER

Local heat stress

Passive heat-stress using a commercial heating pad applied over the abdomen and part of the torso

Trial Locations (1)

37232

Vanderbilt University, Nashville

All Listed Sponsors

lead

Vanderbilt University

OTHER