389
Participants
Start Date
March 31, 2002
Primary Completion Date
January 31, 2017
Study Completion Date
January 31, 2017
Atomoxetine
10-50 mg, PO. Single dose. Alone or in combination with Yohimbine or Mestinon.
Acarbose
25-100 mg, PO. Single dose.
Pyridostigmine Bromide
30 mg-180 mg PO. Single dose. Alone or in combination with Yohimbine or atomoxetine.
Yohimbine
2.7, 5.4 or 10.8 mg PO. Single dose. Alone or in combination with Atomoxetine or Pyridostigmine.
Midodrine HCl
2.5, 5.0, 7.5, 10 mg PO. Single dose
placebo
PO.Single dose.
Modafinil
50-400 mg PO. Single dose
Octreotide
5-50 µg, S.C. Single dose.
water intake
Tap water 2 onz., 8 oz., 16 oz. PO, alone or in combination with any of the above medications. Single dose.
Diphenhydramine Hydrochloride
12.5 mg-100 mg PO. Single dose. Alone or in combination with Ranitidine
Ranitidine HCL
150-300 mg PO. Single dose. Alone or in combination with Diphenhydramine.
Tranylcypromine
5 - 40 mg PO. Single dose
Ergotamine/ Caffeine
Ergotamine: 1.0 mg PO. Single dose. Caffeine 100 mg PO.Single dose
Celecoxib
50-200 mg PO. Single dose
Pseudoephedrine
15, 30 or 60 mg, PO. Single dose.
Methylphenidate
5 or 10 mg PO. Single dose.
Indomethacin
25, 50 or 75 mg, PO. Singe dose.
Ibuprofen
300, 600 or 900 mg, PO. Single dose.
Oxymetazoline 0.05% nasal solution
1-2 sprays/ nostril. Single dose.
Bovril
6-10 g, PO. Single dose.
Acetazolamide
125-1000 mg PO. Single dose. Alone or in combination with yohimbine or midodrine
Rivastigmine tartrate
1.5-6 mg PO. Single dose.
Carbidopa/levodopa
10mg/100mg or 25mg/100mg. 1-2 tab PO. Single dose. Alone or in combination with carbidopa (Lodosyn) 25-175 mg
Inflatable abdominal binder
External abdominal compression (20-40 mm Hg) with an inflatable abdominal binder applied after a pressor agent (e.g. midodrine, yohimbine).
inflatable abdominal binder (sham)
External abdominal compression (5 mm Hg) with an inflatable abdominal binder applied after a pressor agent (e.g. midodrine, yohimbine).
Vanderbilt University, Nashville
Vanderbilt University
OTHER