Combination Therapy in Patients With Relapsing-Remitting Multiple Sclerosis (MS)CombiRx

PHASE3CompletedINTERVENTIONAL
Enrollment

1,008

Participants

Timeline

Start Date

January 31, 2005

Primary Completion Date

April 30, 2012

Study Completion Date

March 31, 2013

Conditions
Relapsing Remitting Multiple Sclerosis
Interventions
DRUG

Interferon beta 1-a

The single agent arm is divided into two groups, IFN and GA providing for 3 treatment arms: IFN IM and GA SC (50% of the patients), IFN IM and placebo SC (25% of the patients) and GA SC and placebo IM (25% of the patients).

DRUG

glatiramer acetate

The single agent arm is divided into two groups, IFN and GA providing for 3 treatment arms: IFN IM and GA SC (50% of the patients), IFN IM and placebo SC (25% of the patients) and GA SC and placebo IM (25% of the patients).

OTHER

placebo

an inactive substance

Trial Locations (71)

10029

Icahn School of Medicine at Mount Sinai, New York

10032

Columbia University Medical Center, New York

12208

Neuro Associates of Albany, PC, Albany

33124

University of Miami - Neurology, Miami

45415

Neurology Specialists, Dayton

85741

Northwest Neurospecialists PLLC, Tucson

95817

University of California - Davis Medical Center, Sacramento

Unknown

University of Alabama - Birmingham, Birmingham

Barrow Neurology Clinic, Phoenix

Mayo Clinic - Scottsdale, Scottsdale

Sutter East Bay Medical Group, Berkeley

Neurology Center North Orange County, La Habra

VA West Los Angeles Healthcare Center, Los Angeles

Alpine Clinical Research Center, Boulder

Patricia Fodor P.C., Colorado Springs

University of Colorado Health Sciences Center, Denver

Yale University School of Medicine, New Haven

Neurology Associates, PA, Maitland

MS Center of Atlanta, Atlanta

Shepherd Center, Atlanta

Northwest University, Chicago

Consultants in Neurology - Multiple Sclerosis Center, Northbrook

University of Illinois College of Medicine, Peoria

Ruan Neurology Clinic and Research Center, Des Moines

University of Kansas Medical Center, Kansas City

Maryland Center for MS, Baltimore

Tufts-New England Medical Center, Boston

University of Massachusetts Memorial Medical Center, Boston

Lahey Clinic, Burlington

Wayne State University, Detroit

Michigan State University, East Lansing

Minneapolis Clinic - MS Center, Golden Valley

Mayo Clinic - Rochester, Rochester

St. Louis University - St. Louis VA, St Louis

Washington University School of Medicine, St Louis

Northern Rockies MS Center, Billings

Dartmouth Medical School, Lebanon

CentraState Medical Center, Freehold

University of New Mexico, Albuquerque

Albany Medical College, Albany

The Jacobs Neurological Institute, Buffalo

Winthrop Neurology Faculty Practice, Mineola

NYU Hospital For Joint Diseases, New York

South Shore Neurologic Associates Inc., Patchogue

University of Rochester, Rochester

SUNY Upstate Medical University, Syracuse

CMC-Neuroscience & Spine Institute, Division of Neurology, MS Center, Charlotte

Meritcare Neuroscience, Fargo

NeuroCare Center, Inc., Canton

Cleveland Clinic, Cleveland

Ohio State University, Columbus

Medical College Of Ohio, Toledo

Oak Clinic for Multiple Sclerosis, Uniontown

University of Pennsylvania, Philadelphia

Allegheny MS Treatment Center, Pittsburgh

Vanderbilt University Medical Center, Nashville

Baylor College of Medicine, Houston

University of Texas - Houston, Houston

University of Utah, Salt Lake City

Neurological Research Center, Inc., Bennington

Fletcher Allen Health Care, Burlington

Neurological Associates, Inc., Richmond

Virginia Commonwealth University, Richmond

MS Center at Evergreen, Seattle

Virginia Mason Medical Center, Seattle

Marshfield Clinic, Marshfield

Regional MS Center at St. Luke's Medical Center, Milwaukee

Foothills Medical Centre, Calgary

Capital Health and the University of Alberta, Edmonton

Ottawa Hospital, Ottawa

St. Michael's Hospital-Multiple Sclerosis Research Center, Toronto

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

lead

Fred Lublin

OTHER