Neoadjuvant TAC Plus or Minus Bevacizumab(AVF3299)

PHASE2CompletedINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

May 31, 2005

Primary Completion Date

June 30, 2012

Conditions
Breast Cancer
Interventions
DRUG

Bevacizumab 7.5 and TAC

Bevacizumab given intravenously at a dose of 7.5mg/kg every 3 weeks, followed by docetaxel, doxorubicin and cyclophosphamide (TAC).

DRUG

Placebo 7.5 and Docetaxel, Doxorubicin, and Cyclophosphamide (TAC)

placebo 7.5 will be adminitered intravenously every 3 weeks followed by TAC

DRUG

Bevacizumab 15 and TAC

one dose of Bevacizumab (15 mg/kg) will be administered intravenously every 3 weeks followed by TAC.

DRUG

Placebo 15 and TAC

one dose of placebo 15 will be administered intravenously every 3 weeks followed by TAC.

Trial Locations (9)

4

St. Vincent's University Hospital, Dublin

8

St. James's Hospital, Dublin

30060

Northwest Georgia Oncology Centers, P.C., Marietta

32804

Cancer Institute of Florida, P.A., Orlando

78207

South Texas Oncology and Hematology, P.A., San Antonio

90095

UCLA Medical Center, Los Angeles

91767

Wilshire Oncology Medical Group, Inc., Pomona

T6G 1Z2

Cross Cancer Institute, Edmonton

H2W 1S6

McGill University, Montreal

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Translational Oncology Research International

OTHER

NCT00203372 - Neoadjuvant TAC Plus or Minus Bevacizumab(AVF3299) | Biotech Hunter | Biotech Hunter