26
Participants
Start Date
December 31, 2003
Primary Completion Date
January 31, 2006
Study Completion Date
December 31, 2009
Citrulline
Phase I - 150mg/kg IV bolus after initiation of cardiopulmonary bypass with dosage escalation study 50mg/kg, 100mg/kg, 150mg/kg IV at 6, 12, 24, 48 hours post operative. Phase II - 150mg/kg IV bolus after initiation of cardiopulmonary bypass with 9mg/kg/hr continuous IV starting 4 hours post bolus and infusing for 48 hours or discharge from PCCU.
Vanderbilt University, Nashville
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Vanderbilt University
OTHER