Safety Study of Radio-labeled huA33 Antibody in Colorectal Cancer

NACompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

February 29, 2004

Primary Completion Date

July 2, 2025

Study Completion Date

July 2, 2025

Conditions
Colorectal NeoplasmsColorectal CancerColorectal TumorCOlorectal Carcinoma
Interventions
DRUG

Iodine-124 labeled humanized A33 (antibody)

Patients will receive a single intravenous or intraarterial infusion of 10mg huA33, labeled with 4mCi-10mCi of 124I in 5-30ml of 5% HSA in normal saline (NS), over 5-10 minutes. On study days 2, 3, and/or 4 patients will have the option to receive up to 2g/kg of IVIG. Patients will be evaluated with 124I-huA33 positron-emission tomography (PET) with ex vivo quantitation of tumor uptake.

Trial Locations (1)

10065

Memorial Sloan Kettering Cancer Center, New York

Sponsors
All Listed Sponsors
collaborator

Ludwig Institute for Cancer Research

OTHER

lead

Memorial Sloan Kettering Cancer Center

OTHER