Allogeneic Transplantation From Related Haploidentical Donors

TLI and ATG infusion of the donor graft Post-transplant immunosuppression with cyclosporine and mycophenolate mofetil.

1.5 mg/kg QD x 5, IV. Dosage will be based on body weight. Purified, sterile IgG fraction of immune serum of rabbits immumixied with human thymus lymphocyte. This drug acts to modify the number and function of lymphocytes.

6.25 mg/kg BID, PO.Mechanism of action is inhibition of T-cell activation by binding to a cytoplasmic protein (cyclophillin).

15 mg/kg Q 8 hours, PO. Inhibtis the enzme inosine monophsophate dehydrogenase (MPDII) noncompetitively which blocks the de nobo synthesis of guanosine required for DNA synthesis and has an effect on T and B cells.

16 mg/kg, SQ Growth factor used to make bone marrow produce more blood cells

1.0 mg/kg IV 2 hours prior to ATG Used to treat severe inflamation

650 mg PO, 30 minutes prior to infusion Pain reliever

50 mg IV, 30 minutes prior to infusion Used to relieve allergy symptoms

100 mg IV, 1 hour prior to infusion Used to relieve itching, redness and swelling of the skin