Caffeine for Apnea of Prematurity (CAP)

PHASE3CompletedINTERVENTIONAL
Enrollment

2,000

Participants

Timeline

Start Date

October 31, 1999

Primary Completion Date

March 31, 2007

Study Completion Date

July 31, 2016

Conditions
Apnea of Prematurity
Interventions
DRUG

Caffeine citrate injection

"Loading dose: 20 mg/kg administered over at least 30 minutes via IV infusion or over at least 10 minutes via slow IV injection.~Daily maintenance dose (to commence at least 24 hours after loading dose): 5 mg/kg, administered over at least 10 minutes via IV infusion, or over at least 5 minutes via slow IV injection. Maintenance dose to be adjusted for body weight every 7 days. If indicated, maintenance dose may be increased to a maximum of 10 mg/kg. May be given orally once full enteral feeds are established.~Duration of treatment: discontinue after infant has tolerated at least 5 consecutive days without positive pressure support AND when the infant is judged by the attending clinician to be no longer a candidate for methylxanthine therapy."

Trial Locations (34)

1211

University Hospitals of Geneve, Geneva

2605

Canberra Hospital, Canberra

3002

Mercy Hospital for Women, Melbourne

3053

Royal Women's Hospital, Melbourne

5006

Women's & Children's Hospital, Adelaide

11201

Brooklyn Hospital Center, Brooklyn

44281

Meir General Hospital, Kfar Saba

81377

Ludwig Maximilian University, Munich

84101

Soroka University Medical Center, Beersheba

T2N 4N1

Foothills Hospital, Calgary

V6H 3V4

Children's & Women's Health Centre of BC, Vancouver

V8Z 6R5

Victoria General Hospital, Victoria

R2H 2A6

St. Boniface General Hospital, Winnipeg

E1C 6Z8

Moncton Hospital, Moncton

L8S 4J9

McMaster University, Hamilton

K7L 2V7

Kingston General Hospital, Kingston

K1H 8L6

Ottawa Hospital, Ottawa

M5G 1X5

Mount Sinai Hospital, Toronto

M5S 1B2

Sunnybrook & Women's College Health Science Centre, Toronto

N8W 1L9

Windsor Regional Hospital, Windsor

H3A 1A1

Royal Victoria Hospital, Montreal

J1H 5N4

University of Sherbrooke, Sherbrooke

S7N 0W8

Royal University Hospital, Saskatoon

G1L 3L5

Centre Hospitalier Universitaire de Quebec, Québec

D-72076

University of Tuebingen, Tübingen

Unknown

Kaplan Medical Center, Rehovot

University Hospital Maastricht, Maastricht

1100 DD

Academisch Medisch Centrum, Amsterdam

SE-17176

Astrid Lindgren's Children's Hospital, Stockholm

CH-4005

University Children's Hospital Basel, Basel

CH-8091

University of Zurich, Zurich

BT12 6BB

Royal Maternity Hospital, Belfast

TS4 3BW

South Cleveland Hospital, Middlesbrough

NE1 4LP

Royal Victoria Infirmary, Newcastle upon Tyne

All Listed Sponsors
collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

collaborator

National Health and Medical Research Council, Australia

OTHER

lead

McMaster University

OTHER

NCT00182312 - Caffeine for Apnea of Prematurity (CAP) | Biotech Hunter | Biotech Hunter